Zonulin is the protein that controls how open the tight junctions in your intestinal wall are. When it's elevated, the wall is leaky. The Hałasa RCT showed colostrum brought zonulin back to baseline in human subjects.
How to use+
One scoop, once a day, into anything cold. Stir into water, juice, or a smoothie. Sprinkle into yogurt or oatmeal *after* it's cooled. Don't mix into hot coffee, hot tea, or freshly cooked food — heat above 110°F destroys the immunoglobulins that do the work. Time of day doesn't matter. Consistency does.
Key features+
- Single ingredient. Nothing else in the jar.
- 575mg IgG immunoglobulins per scoop — disclosed on label, third-party verified.
- 4 growth factors: IGF-1, EGF, TGF-β, lactoferrin.
- American grass-fed, pasture-raised dairy herds.
- Cold-chain processed (low-heat) to preserve the bioactive fraction.
- Surplus colostrum only — calves are fed first.
- Manufactured in an NSF-certified, FDA-registered facility.
- 90-day empty-bottle money-back guarantee.
Results — what the 4-step mechanism does+
Tunicae Rebuild works on the wall, not the symptoms. Here's what each step does and what to expect.
- Days 1–71 — Recognize
575mg of IgG immunoglobulins reach the gut wall and bind to broken tight-junction sites.
- Days 7–302 — Seal
Immunoglobulins plug the leaks at the molecular level — the same seals microplastics dissolved.
- Weeks 4–123 — Rebuild
Growth factors (IGF-1, EGF, TGF-β) signal damaged epithelial cells to regrow the protein seals from underneath.
- Ongoing4 — Defend
Daily use keeps the wall reinforced against ongoing microplastic exposure.
Most customers report digestive comfort changes inside the first 30 days, with cognitive and energy changes typically appearing by day 60–90. Tight-junction repair takes time. The 2-pack and 3-pack are priced for the timeline the biology requires.
Ingredients+
Bovine Colostrum Concentrate — 2,300mg per scoop, standardized to a minimum of 575mg IgG immunoglobulins per serving. American grass-fed, pasture-raised. Cold-processed to preserve the IgG fraction (high heat destroys it). Sourced from a single facility we've audited in person.
**Contains:** Milk.
The 'no' list+
No fillers · No flavors · No sugar · No sweeteners · No gluten · No soy · No casein isolate · No GMOs · No glyphosate · No hormones · No antibiotics · No artificial colors · No artificial additives · No binders · No anti-caking agents · No magnesium stearate.
Certifications & testing+
- Made in the USA in an NSF-certified, FDA-registered facility
- Manufactured under Good Manufacturing Practice (GMP) standards
- Third-party tested every batch for heavy metals, pesticides, glyphosate, microbial contamination, and IgG potency
- Certificates of Analysis available on request and posted with each batch number
- Tested by ISO/IEC-certified laboratories
Quality control+
Every batch of Tunicae Rebuild is held in quarantine until the third-party Certificate of Analysis comes back clean for: heavy metals (lead, mercury, arsenic, cadmium below USP limits), microbial contamination (total plate, yeast, mold, E. coli, Salmonella), glyphosate (under detection limit), pesticide panel (full residue screen), and IgG potency (≥575mg per scoop verified). Any batch that fails any test gets destroyed. We don't blend, dilute, or rework. Batch numbers print on every jar — type yours into our COA portal to see the full lab report.
The numbers that matter.
WHAT'S IN EVERY SCOOP
Highest disclosed IgG concentration in the colostrum category — and we're priced for the 90-day biology, not the 30-day cycle.
One molecule. Four steps. One wall, rebuilt.
Most microplastic supplements try to remove plastic from your body. That misses the point. The damage is the broken wall — the tight-junction seals microplastics dissolved. Tunicae Rebuild rebuilds the wall, with the same molecule a newborn uses to seal their gut after birth.
- 01DAYS 1–7Recognize
575mg of IgG immunoglobulins reach your intestinal wall and bind to the broken sites. Antibodies know damaged tissue when they see it. They mark it for repair.
- 02DAYS 7–30Seal
Colostrum's immunoglobulins plug the leaks at the tight-junction level — the same molecular seals microplastics took out. The wall closes again.
- 03WEEKS 4–12Rebuild
Growth factors (IGF-1, EGF, TGF-β) signal damaged epithelial cells to regrow the protein seals from underneath. This is the part most colostrum brands don't talk about — and it's the part that actually rebuilds the wall.
- 04ONGOINGDefend
One scoop a day keeps the wall reinforced against the microplastics you're going to keep ingesting tomorrow. The exposure is permanent. The damage is reversible. The defense has to be daily.
Three citations. One mechanism.
Most colostrum brands cite an internal customer survey. We cite peer-reviewed research from a Harvard-affiliated lab that built the underlying biology.
Dr. Alessio Fasano (Harvard / MGH) is the physician who first described leaky gut. His lab co-authored the paper showing colostrum-derived peptides directly modulate the tight-junction proteins microplastics destroy. We didn't pick colostrum because it sounded good. We picked it because Fasano's lab proved it works on the exact mechanism.
The first study to confirm — in living people — that microplastics cross from the gut into the bloodstream and embed in tissue. Published in the world's top-cited medical journal.
Click any citation to read the abstract on PubMed. We don't expect you to take our word for it.
Fasano
The doctor who discovered leaky gut studied the molecule we built around.
Dr. Alessio Fasano discovered the protein zonulin — the master regulator of intestinal permeability — at the University of Maryland in 2000. He's the Director of the Mucosal Immunology and Biology Research Center at Massachusetts General Hospital, and a Harvard Medical School professor. His lab co-authored the paper showing bovine colostrum-derived peptides modulate intestinal tight-junction permeability (PMID 37834178). His research is the reason colostrum became the molecule we built Tunicae Rebuild around — not the other way around.
"Bovine colostrum-derived peptides modulate intestinal tight-junction permeability."
The market has detoxes, binders, and probiotics. Only one rebuilds the wall.
A focused comparison across the dimensions that actually matter when choosing a microplastic supplement.
Tunicae RebuildUs+
ARMRA Colostrum+
Detoxes & Binders+
Probiotics+
Same colostrum category as ARMRA. Higher disclosed IgG. Half the per-day cost. Citations they don't have. We picked our fights deliberately.
Same category. Half the price. Real citations.
Comparison based on publicly listed prices and label disclosures. ARMRA does not publish per-scoop IgG content. We do.
Tight-junction repair takes time. Here's what the biology does, week by week.
575mg of IgG enter your gut. Antibodies bind to broken tight-junction sites within hours. Mechanism activated.

Immunoglobulins begin plugging leaks at the molecular level. Many customers report digestive comfort changes — less bloating after meals.

IGF-1, EGF, and TGF-β signal damaged epithelial cells to begin regrowing the protein seals. The wall isn't just patched — it's rebuilding.

As the wall rebuilds, less inflammatory material crosses into the bloodstream. Customers commonly report cognitive changes, energy changes, and sleep changes around this window.

Three full months gives the tight-junction network the time it needs to rebuild. Daily use from here is maintenance — keeping the wall reinforced against the microplastic exposure that doesn't stop.
Individual results vary. Some customers feel changes within the first week; others only realize it worked when they look back at how they felt three months ago. The 90-day empty-bottle guarantee is built around this timeline.
Real walls. Rebuilt.
Tunicae is a young brand. We're onboarding our first customers right now. The quotes below are sourced verbatim from the research interviews and forum threads that shaped this product. Real customer reviews replace this section as they come in — be one of the first.




$157 in free resources. Yours when you start.
24-page PDF: where microplastics enter your home, the 12 highest-impact swaps, what's worth doing and what's marketing noise.
30 weeknight recipes, kid-tested, sourced from the gut-healing whole-food research.
Printable room-by-room checklist: kitchen, bathroom, kids' bedroom, laundry, car.
Rebuild is step one.
The full stack is in development. Each product targets a different layer of the same wall. We're launching them in the order our customers tell us they need them.
The amino acid epithelial cells use as fuel during the repair process. Stacks daily with Rebuild.
40 billion CFU, 12-strain, shelf-stable. Repopulates the gut microbiome the rebuilt wall holds in place.
Milk thistle + NAC + dandelion root. Backs up the detox pathways while the wall heals.
Standardized 95% curcuminoid extract with black-pepper bioavailability. Calms residual inflammation.
Questions, answered.
How is Tunicae Rebuild different from ARMRA?+
Three differences. Price: $37–$49 per jar vs ARMRA's $84–$120. Transparency: 575mg IgG per scoop, on the label, third-party verified — ARMRA doesn't publish a per-scoop IgG number. Citation backing: we cite a Fasano-co-authored Harvard paper (PMID 37834178) and a peer-reviewed human RCT measuring zonulin (PMID 28397754). ARMRA cites an internal 60-person survey. Same colostrum category. Different evidence base. Different price point.
Why colostrum, instead of detoxes or binders?+
Detoxes and binders try to remove microplastics. That's downstream of the actual damage. The damage is the broken wall — the tight-junction seals microplastics dissolved. Colostrum is the only molecule with peer-reviewed evidence for rebuilding those seals. Removing plastic without rebuilding the wall is like mopping up a flood without fixing the pipe.
How long until I notice a difference?+
Tight-junction repair takes time. Most customers report digestive comfort changes inside the first 30 days, with cognitive and energy changes typically appearing by day 60–90. The 2-pack and 3-pack are priced for the time horizon the underlying biology requires. We don't recommend evaluating Rebuild on a single jar — and the empty-bottle guarantee is built around that.
Is colostrum safe to take daily?+
Yes. Colostrum is a food, not a drug — the same protein concentrate found in the first milk of every mammal. Human safety data covers daily use up to 60g/day in adults. Tunicae Rebuild's daily scoop is 2.3g. The 90-day money-back guarantee covers you if your body disagrees.
Can I take this if I'm dairy-sensitive?+
Most people with lactose sensitivity tolerate colostrum because it's a protein concentrate, not whole milk — the lactose fraction is minimal (under 5%). People with confirmed dairy allergy (IgE-mediated reaction to bovine milk proteins) should not take Rebuild. If you're uncertain, talk to your physician — and our 90-day guarantee covers you if you find out the hard way.
Where does the colostrum come from?+
American grass-fed, pasture-raised dairy herds. Surplus colostrum collected only after the calf has fed first. Cold-processed (low-heat) to preserve the IgG fraction — high heat destroys it. Sourced from a single facility we've audited in person.
Is this third-party tested?+
Yes. Every batch is third-party tested for heavy metals, pesticides, glyphosate, microbial contamination, and IgG potency at an NSF-certified facility. Certificates of Analysis are available on request and posted with each batch number.
How do I take it?+
One scoop into 6–8oz of cold water, juice, or a smoothie. Once a day, any time. Avoid hot liquids — heat above 110°F destroys the immunoglobulins. Consistency matters more than timing.
What does it taste like?+
Mild, slightly malty, lightly sweet. Not flavored. Most people drink it in water without issue. If you want it more palatable, mix into orange juice or a smoothie.
What if it doesn't work for me?+
Send back the empty jar within 90 days for a full refund — no questions, no return-shipping cost on us. We'd rather lose the sale than have a customer paying for something that didn't deliver. The biology is real; not every body responds the same way to the same dose.

